| 期刊論文 | (2004), "Expression of matrix metalloproteinase-3 in oral tumors from southern Taiwan and its correlation with both tumor stage and lymph node metastasis." Chinese Dental Journal, 23, 1. (SCI) |
| (2004), "The synergistic cytotoxicity of cisplatin and taxol in killing oral squamous cell carcinoma." Japanese Journal of Clinical Oncology, 34, 9. (SCI) |
| (2004), "Effects of psyllium on plasma total and lipoprotein cholesterol and hepatic cholesterol in hamsters fed n-3 PUFA or n-6 PUFA with high cholesterol levels." Annals of Nutrition & Metabolism, 48, 10. (SCI) |
| (2004), "The amount of dietary cholesterol changes the mode of effects of (n-3) polyunsaturated fatty acid on lipoprotein cholesterol in hamsters." Annals of Nutrition and Metabolism, 48, 5. (SCI) |
| (2005), "Areca quid chewing enhances the expression of salivary matrix metalloproteinase-9." Journal of the Formosan Medical Association, 104, 2. (SCI) |
| (2005), "Increased expression of matrix metalloproteinase-2 in oral cells after short-term stimulation and long-term usage by areca quid." Journal of the Formosan Medical Association, 104, 6. (SCI) |
| (2005), "A High-Cholesterol, n-3 Polyunsaturated Fatty Acid Diet Causes Different Responses in Rats and Hamsters.." Annals of Nutrition & Metabolism, 49, 6. (SCI) |
| (2007), "Requirement of MMP-3 in anchorage-independent growth of oral squamous cell carcinomas." Journal of Oral Pathology and Medicine, 36, 2. (SCI) |
| (2005), "The universal expression pattern of the matrix metalloproteinase-1 in oral tumor specimens from Southern Taiwan." Chia Nan Annual Bulletin, 0, 31. (其他) |
| (2006), "Functional role of matrix metalloproteinase-28 in the oral squamous cell carcinoma." Oral Oncology, 42, 9. (SCI) |
| (2007), "Up-regulation of matrix metalloproteinase-8 by betel quid extract and arecoline and its role in 2D motility." Oral Oncology, 43, 10. (SCI) |
| (2008), " Upregulation of matrix metalloproteinase-1 (MMP-1) expression in oral carcinomas of betal quil (BQ) users: roles of BQ ingredients in the acceleration of tumor cell motility through MMP-1." Archives of Oral Biology, 53, 9. (SCI) |
| (2008), "Autophagy induction by a natural ingredient of areca nut." Autophagy, 4, 7. (SCI) |
| (2008), "Arecoline and the 30-100 kDa fraction of areca nut extract differentially regulate mTOR and respectively induce apoptosis and autophagy: a pilot study." Journal of Biomedical Science, 15, 6. (SCI) |
| (2010), "Possible Mechanism of Betel-quid-extract-induced Expression of Matrix Metalloproteinase-2." Journal of the Formosan Medical Association, 109, 11. (SCI) |
| (2010), "Autophagy induction by the 30–100 kDa fraction of areca nut in both normal and malignant cells through reactive oxygen species." Oral Oncology, 46, 11. (SCI) |
| (2010), "Possible mechanism of betel-quid-extract-induced expression of marix metalloproteinase-2." Journal of the formosan medical association, 109, 0. (SCI) |
| (2010), "Autophagy induction by the 30-100 kDa fraction of areca nut in both normal and malignant cells through reactive oxygen species." Oral oncology, 46, 0. (SCI) |
| (2011), "Arecoline-mediated inhibition of AMP-activated protein kinase through reactive oxygen species is required for apoptosis induction." Oral oncology, 47, 0. (SCI) |
| Yen CY, Chiang WF, Liu SY, Cheng PC, Lee SY, Hong WZ, Lin PY, Lin MH and Liu YC(2014), "Long-term stimulation of areca nut components results in increased chemoresistance through elevated autophagic activity." Journal of Oral Pathology and Medicine, 43, 2. (SCI) |
| Ching-Tu Yen, Wei-Fan Chiang, Shyun-Yeu Liu, Chung-Chih Lin, Kuo-An Liao, Che-Yi Lin, Wan-Fang Hsieh, Yon-Chi Cheng, Kai-Cheng Hsu, Pin-Yen Lin, Tai-Chi Chen, I-Ling Lee, Mei-Huei Lin, Young-Chau Liu(2015), "Impacts of Autophagy-Inducing Ingredient of Areca Nut on Tumor Cells." PLOS ONE, 10, 5. (SCI) |
| Ching-Yu Yen, Shyun-Yeu Liu, Mei-Huei Lin, Young-Chau Liu(2016), "Areca Nut contains both Apoptosis- and Autophagy-inducing Ingredients and its Possible Effects on Cancer Cells." Journal of Biomedical Sciences, 5, 1. (其他) |
| Mei-Huei Lin1,2 | Young-Chau Liu2,3 | Shyun-Yeu Liu4,5,6 | Fang-Chi Chen1 |
Pei-Jung Yang1 | Guan-Hua Li1 | Pang-Yen Liu1 | Ching-Yu Yen4,5,6(2017), "Clathrin-mediated endocytosis is required for ANE 30-100K-induced autophagy." Journal of Oral Pathology and Medicine, 47, 0. (SCI) |
| CHANG-TA CHIU, SHYUN-YEU LIU, CHING-YU YEN*, BANG-YEN LIU,ZI-YU SUN, CHUN-YI WU, JI-LUNG DENG, YOUNG-CHAU LIU and MEI-HUEI LIN
ZI-YU SUN, CHUN-YI WU, JI-LUNG DENG, YOUNG-CHAU LIU4,5 and MEI-HUEI LIN3,4(2020), "Chronic Stimulation of the Autophagy-inducing Ingredient of Areca Nut Promotes Tumor Growth In Vivo Through Up-regulation of Tumoral Autophagy." ANTICANCER RESEARCH, 40, 0. (SCI) |
| Chang-Ta Chiu, Che-Yi Lin, Ching-Yu Yen, Meng-Ting Tsai, Huei-Cih Chang, Young-Chau Liu, Mei-Huei Lin(2020), "Mechanistic and compositional studies of the autophagy-inducing areca nut ingredient." Journal of Dental Sciences, 0, 15. (SCI) |
| 專書 | , The Living Word, 歐亞書局有限公司與學銘圖書有限公司, 2004年出版(ISBN 957-493-891-3). |
| , Concepts in Biochemistry, 學銘圖書有限公司，歐亞書局有限公司, 2002年出版(ISBN 978-986-82003-9-5). |
| 張峻凱、林美惠、羅怡珮、賴雪端、田乃月、高毓瑩, 生物學(The Living Word，George B. Johnson原著), 歐亞書局有限公司, 2014年09月出版(ISBN 978-986-341-103-1). |
| 研究計畫 | 檳榔子誘導細胞姿體吞噬的作用在口腔細胞從正常'癌前病變到惡性轉變的進程ˊ中所扮演的角色 |
| 由檳榔子萃取液 30-100 kDa的部分所誘導的自體吞噬之途徑 |
| 經檳榔子長期刺激後在口腔腫瘤細胞中與自體吞噬相關的基因表達與腫瘤進展之相關性 |
| 由檳榔子萃取液 30-100 kDa的部分所誘導的自體吞噬之途徑 |
| 誘導自體吞噬的檳榔子成分對腫瘤細胞的影響(一) |
| AMPK 在 ANE 30-100K所誘導的自體吞噬中所扮演的角色 |
| 不同的自體吞噬抑制劑對 ANE 30-100K 誘導的自體吞噬有不同的效果-在不同類型的自體吞噬中是黩特的或普遍的現象 |
| 腫瘤細胞經誘導自體吞噬的檳榔子成分長期刺激後的改變 |
| 將抑制自體吞噬包含在內的策略可能是對檳榔子上癮的嚼食者新的癌症治療方向 |
| 對檳榔子中誘導自體吞噬成分的分子與機轉分析 |
| 檳榔子中誘導自體吞噬成分的純化 |
| 將抑制自體吞噬包含在內的策略可能是對檳榔子上癮的嚼食者新的癌症治療方向 |
| 計畫主持人 | 樟芝、雷公藤、薄葉牛皮消對乳癌細胞之增生抑制探討 |
| 不同的檳榔子成分所引起之不同死亡形式 |
| 檳榔成分誘發細胞自體吞噬訊息傳導路徑之探討 |
| 口腔癌患者唾液中基質金屬蛋白酵素的偵測 |
| 檳榔萃取液對第二型與第八型基質金屬蛋白誘導機轉之探討 |
| 第三型與第二十八型基質金屬蛋白在南台灣口腔狀細胞表皮癌中所扮演的角色 |
| 口腔癌細胞蛋白質二維電泳之分析 |
| 第一型基質金屬蛋白酵素在南臺灣口腔腫 |
| Cisplatin but not carboplatin acts synergistically with Taxol in killing the oral squamous cell carcinoma cell line |
| Mechanisms implicated in the crude extract of betel quid induced matrix metalloproteinase-2 |
| 不同的檳榔子成份所誘導的細胞凋亡與自體吞噬之探討 |
| 檳榔萃取液30-100K與檳榔素所誘導的死亡訊息傳遞之比較 |
| 檳榔子成分對口腔細胞的影響(二)-Beclin 1與Atg5在ANE30-100K誘導的自體吞噬中所扮演的角色 |
| 抑制自體吞噬對經檳榔子成分長期刺激後的食道癌細胞提升順鉑療效脂機轉研究-經刺激的上皮癌細胞可能比未經刺激的細胞對抑制自體吞噬更為敏感 |
| 榮譽 | 85學年度國科會第一期甲種生物處室研究獎助 |