姓名吳明娟
職稱教授
聯絡電話2520
電子郵件imwu@mail.cnu.edu.tw
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期刊論文(2002), "台灣嘉南地區居民血液中同半胱胺酸濃度與年齡及性別之相關性探討." 中華民國營養學會雜誌, 2, 27. (其他)
(2002), "Effects of age and gender on mean plasma homocysteine levels in inhabitants of the Chianan region of Taiwan.." Nutritional Sciences Journal, 27, 1. (其他)
(2002), "Multiplex PCR for the simultaneous detection of the SEA, SEB, SEC, SED and SEE genes of enterotoxigenic Staphylococcus aureus.." Journal of Food and Drug Analysis, 10, 0. (其他)
(2002), "Antioxidant activities of azuki beans and pods (Vigna angularis).." Vigna angularis, 0, 4. (其他)
(2003), "Antioxidant activity of methanol extract of the lotus leaf (Nelumbo nucifera Gertn.)." American Journal of Chinese Medicine, 5, 31. (SCI)
(2004), "Antioxidant Activity of Porcelainberry (Ampelopsis brevipedunculata(Maxim.) Trautv.)." American Journal of Chinese Medicine, 5, 32. (SCI)
(2004), "Anti-Inflammatory and Antiviral Effects of Glossogyne tenuifolia." Life Science, 10, 76(10). (SCI)
(2004), "Glossogyne tenuifolia Acts to Inhibit Inflammatory Mediator Production in a Macrophage Cell Line by Down-Regulating LPS-Induced NF-kB.." Journal of Biomedical Science, 2, 11. (SCI)
(2005), "Anti-Inflammatory and Antiviral Effects of Glossogyne tenuifolia." Journal Ethnopharmacology, USA, 紐約. (SCI)
(2005), "Antioxidant activity of Glossogyne tenuifolia.." Journal of Agricultral and Food Chemistry, 16, 53. (SCI)
(2005), "Immunomodulatory mechanism of the aqueous extract of sword brake fern (Pteris ensiformis Burm.).." Journal Ethnopharmacology, 1-2, 98. (SCI)
(2005), "Immunomodulatory mechanism of the aqueous extract of sword brake fern (Pteris ensiformis Burm.).." Journal Ethnopharmacology, 1-2, 98. (SCI)
(2005), "Antioxidant activity of Glossogyne tenuifolia.." Journal of Agricultral and Food Chemistry, 16, 53. (SCI)
(2005), "Anti-Inflammatory and Antiviral Effects of Glossogyne tenuifolia." Journal Ethnopharmacology, USA, 紐約. (SCI)
(2005), "Single Nucleotide Polymorphism of the CTLA-4 Gene Is Associated with Susceptibility to Graves’ Disease in the Taiwanese Population." Disease in the Taiwanese Population, 3, 35. (SCI)
(2006), "Immunomodulatory Effect of Glossogyne tenuifolia in Murine Peritoneal Macrophages and Splenocytes." Journal of Ethnopharmacology, 107, 1. (SCI,)
(2006), "Distinctive Antioxidant and Anti-Inflammatory Effects of Flavonols." Journal of Agricultural and Food Chemistry, 26, 54. (SCI,)
(2006), "Ganoderma lucidum Mycelia Enhance Innate Immunity by Activating NF-B." Journal of Ethnopharmacology, 103, 2. (SCI,)
(2006), "Immunomodulatory Properties of Grifola frondosa in Submerged Culture.." Journal of Agricultural and Food Chemistry, 54, 8. (SCI,)
(2006), "Abnormal glucose tolerance and insulin resistance in polycystic ovary syndrome amongst the Taiwanese population- not correlated with insulin receptor substrate-1 Gly972Arg/Ala513Pro polymorphism." BMC Medical Genetics, 7, 7. (其他,)
(2007), "Inhibition of Low-Density Lipoprotein Oxidation and Oxidative Burst in Polymorphonuclear Neutrophils by Caffeic Acid and Hispidin Derivatives Isolated from Sword Brake Fern (Pteris ensiformis Burm.)." J. Agri. Food Chem, 55, 26. (SCI,)
(2007), "Antiatherogenic Effects of Kaempferol and Rhamnocitrin." J. Agri. Food Chem, 55, 24. (SCI,)
(2007), "Identification of Phenolic Antioxidants from Sword Brake Fern (Pteris ensiformis Burm.)." Food Chemistry, 105, 1. (SCI,)
(2007), "Immunomodulatory effect of exo-polysaccharides from submerged cultured Cordyceps sinensis: enhancement of cytokine synthesis, CD11b expression, and phagocytosis." Applied Microbiology and Biotechnology, 4, 75. (SCI,)
(2008), "Identification of Antioxidants from Rhizome of Davallia solida." Food Chemistry, 107, 2. (SCI)
(2008), "New benzoyl glucosides and cytotoxic pterosin sesquiterpenes from Pteris ensiformis burm." Molecules, 13, 0. (SCI)
(2008), "Oral administration of submerged cultivated Grifola frondosa enhances phagocytic activity in normal mice.." Journal of Pharmacy and Pharmacology, 60, 2. (SCI)
(2008), "Fisetin, morin and myricetin attenuate CD36 expression and oxLDL uptake in U937-derived macrophages.." Biochimica et Biophysica Acta-Molecular and Cell biology of Lipids, 1781, 10. (SCI)
(2008), "Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate." Journal of Ethnopharmacology, 120, 2. (SCI)
(2009), "Cyphomandra betacea Sendt. phenolics protect LDL from oxidation and PC12 cells from oxidative stress.." Lwt-Food Science and Technology, 42, 2. (SCI)
(2009), "Regulation of Heme Oxygenase-1 Expression and MAPK Pathways in Response to Kaempferol and Rhamnocitrin in PC12 Cells.." Toxicology and Applied Pharmacology, 237, 1. (SCI)
(2010), "Nobiletin metabolite, 3',4'-dihydroxy-5,6,7,8-tetramethoxyflavone, inhibits LDL oxidation and down-regulates scavenger receptor expression and activity in THP-1 cells.." Biochimica et Biophysica Acta, 1801, 2. (SCI)
(2010), "Neurotrophic and cytoprotective action of luteolin in PC12 cells through ERK-dependent induction of Nrf2-driven HO-1 expression.." Journal of Agricultural and Food Chemistry, 58, 7. (SCI)
(2011), "α-Lipoic acid inhibits liver fibrosis through the attenuation of ROS-triggered signaling in hepatic stellate cells activated by PDGF and TGF-β." Toxicology, 282, 1-2. (SCI)
(2011), "Lipoic acid ameliorates arsenic trioxide-induced HO-1 expression and oxidative stress in THP-1 monocytes and macrophages." Chemico-Biological Interactions, 0, 0. (SCI)
(2011), "Citrus flavonoid, 5-demethylnobiletin, suppresses scavenger receptor expression in THP-1 cells and alters lipid homeostasis in HepG2 liver cells.." Molecular Nutrition & Food Research, 0, 0. (SCI)
(2012), "3',4'-didemethylnobiletin induces Phase II detoxification gene expression and modulates PI3K/Akt signaling in PC12 cells.." Free Radical Biology & Medicine, 52, 1. (SCI)
(2011), "Neurotrophic Effect of Citrus 5-Hydroxy-3,6,7,8,3',4'-hexamethoxyflavone: Promotion of Neurite Outgrowth via cAMP/PKA/CREB Pathway in PC12 Cells.." PLoS One, 6, 11. (SCI)
(2012), "Curcuminoids Promote Neurite Outgrowth in PC12 Cells through MAPK/ERK- and PKC-Dependent Pathways.." Journal of Agricultural and Food Chemistry, 60, 1. (SCI)
(2012), "Arsenic modulates heme oxgenase-1, interleukine-6 and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB and MAPK pathways.." Archives of Toxicology, 0, 0. (SCI)
Lin LF, Chiu SP, Wu Ming-Jiuan, Chen PY, Yen JH*(2012), "Luteolin induces microRNA-132 expression and modulates neurite outgrowth in PC12 Cells." PLoS One, 7, 8. (SCI)
Kou MC, Chiou SY, Weng CY, Wang L, Ho CT, Wu MJ*(2013), "Curcuminoids distinctly exhibit antioxidant activities and regulate expression of scavenger receptors and heme oxygenase-1." Molecular Nutrition & Food Research, 0, 0. (SCI)
Kou MC, Fu SH, Yen JH, Weng CY, Li S, Ho CT and Wu MJ*(2013), "Effects of citrus flavonoids, 5-hydroxy-3,6,7,8,3’,4’-hexamethoxyflavone and 3,5,6,7,8,3’,4’-heptamethoxyflavone, on the activities of macrophage scavenger receptors and the hepatic LDL receptor." Food & Function, 0, 0. (SCI)
Chiu HW, Chen MH, Fang WH, Hung CM, Chen YL, Wu MD, Yuan GF, Wu MJ*, Wang YJ.(2013), "Preventive effects of monascus on androgen-related diseases: androgenetic alopecia, benign prostatic hyperplasia, and prostate cancer.." Journal of Agricultural and Food Chemistry, 61, 18. (SCI)
Chiu SP, Wu MJ, Chen PY, Ho YR, Tai MH, Ho CT, Yen JH(2013), "Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells.." Journal of Agricultural and Food Chemistry, 61, 39. (SCI)
Weng CY, Chiou SY, Wang L, Kou MC, Wang YJ*, Wu MJ*(2014), "Arsenic trioxide induces unfolded protein response in vascular endothelial cells." Archives of Toxicology, 88, 2. (SCI)
Lin MH, Yen JH, Weng CY, Wang L, Ha CL, Wu MJ*(2014), "Lipid peroxidation end product 4-hydroxy-trans-2-nonenal triggers unfolded protein response and heme oxygenase-1 expression in PC12 cells: roles of ROS and MAPK pathways.." Toxicology, 315, 6. (SCI)
Wang L, Chiou S.-Y., Shen Y.-T., Yen, F.-T., Ding H.-Y., Wu M.-J.(2014), "Anti-Inflammatory Effect and Mechanism of the Green Fruit Extract of Solanum integrifolium Poir.." BioMed Research International, 2014, 2014. (SCI)
Hu LW, Yen JH, Shen YT, Wu KY, Wu MJ*(2014), "Luteolin modulates 6-hydroxydopamine-induced transcriptional changes of stress response pathways in PC12 cells.." PLoS One, 9, 5. (SCI)
Tai MH, Chen PK, Chen PY, Wu MJ, Ho CT, Yen JH(2014), "Curcumin enhances cell-surface LDLR level and promotes LDL uptake through down-regulation of PCSK9 gene expression in HepG2 cells.." Molecular Nutrition & Food Research, 58, 11. (SCI)
1. Chen PY, Ho YR, Wu MJ, Huang SP, Chen PK, Tai MH, Ho CT, Yen JH(2015), "Cytoprotective effects of fisetin against hypoxia-induced cell death in PC12 cells." Food & Function, 6, 1. (SCI)
Chen PY, Wu MJ, Chang HY, Tai MH, Ho CT, Yen JH(2015), "Up-regulation of miR-34a expression in response to the luteolin-induced neurite outgrowth of PC12 cells." Journal of Agricultural and Food Chemistry, 63, 16. (SCI)
Wu PS, Yen JH , Kou MC , Wu MJ(2015), "Luteolin and apigenin attenuate 4-hydroxy-2-nonenal-mediated cell death through modulation of UPR, Nrf2-ARE and MAPK pathways in PC12 cells.." PLoS One, 10, 6. (SCI)
Huang SL, Chen PY, Wu MJ, Tai MH, Ho CT, Yen JH(2015), "Curcuminoids Modulate the PKCδ/NADPH oxidase/ROS Signaling Pathway and Suppress Matrix Invasion during Monocytes-Macrophages Differentiation." Journal of Agriculture and Food Chemistry, 63, 40. (SCI)
Chiou SY, Ha CL, Wu PS, Yeh CL, Su YS, Li MP, Wu MJ(2015), "Antioxidant, Anti-Tyrosinase and Anti-Inflammatory Activities of Oil Production Residues from Camellia tenuifloria.." International Journal of Molecular Sciences, 16, 12. (SCI)
Ding HY, Wu PS, Wu MJ*(2016), "Cleome rutidosperma and Euphorbia thymifolia Suppress Inflammatory Response via Upregulation of Phase II Enzymes and Modulation of NF-kappaB and JNK Activation in LPS-Stimulated BV2 Microglia.." International Journal of Molecular Sciences, 17, 9. (SCI)
Chen HC, Chen PY, Wu MJ, Tai MH, Yen JH*(2016), "Tanshinone IIA Modulates Low Density Lipoprotein Uptake via Down-Regulation of PCSK9 Gene Expression in HepG2 Cells.." PLoS One, 11, 9. (SCI)
Shen KH, Hung JH, Chang CW, Weng YT, Wu MJ, Chen PS(2017), "Solasodine inhibits invasion of human lung cancer cell through downregulation of miR-21 and MMPs expression." Chemico-Biological Interactions, 268, 0. (SCI)
Yen J-H, Wu P-S, Chen S-F, Wu M-J*(2017), "Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells.." International Journal of Molecular Sciences, 18, 4. (SCI)
Chen SF, Chen PY, Hsu HJ, Wu MJ, Yen JH(2017), "Xanthohumol Suppresses Mylip/Idol Gene Expression and Modulates LDLR Abundance and Activity in HepG2 Cells.." J Agric Food Chem, 65, 36. (SCI)
Chen PY, Tien HJ, Chen SF, Tang HL, Jung HL, Wu MJ, Yen JH(2018), "Response of Myeloid Leukemia Cells to Luteolin is Modulated by Differentially Expressed Pituitary Tumor-Transforming Gene 1 (PTTG1) Oncoprotein." Int J Mol Sci., 19, 4. (SCI)
Wu PS, Ding HY, Yen JH, Chen SF, Lee KH, Wu MJ*.(2018), "Anti-inflammatory activity of 8-hydroxydaidzein in LPS-stimulated BV2 microglial cells via activation of Nrf2-antioxidant and attenuation of Akt/NF-kappaB-inflammatory signaling pathways, as well as inhibition of COX-2 activity." J Agric Food Chem, 0, 0. (SCI)
Gao WY, Chen PY, Chen SF, Wu MJ, Chang HY, Yen JH.(2018), "Pinostrobin inhibits proprotein convertase subtilisin/kexin type 9 (PCSK9) gene expression through the modulation of FoxO3a protein in HepG2 cells.." J Agric Food Chem., 66, 24. (SCI)
Chang HY, Wu JR, Gao WY, Lin HR, Chen PY, Chen CI, Wu MJ, Yen JH(2019), "The Cholesterol-Modulating Effect of Methanol Extract of Pigeon Pea (Cajanus cajan (L.) Millsp.) Leaves on Regulating LDLR and PCSK9 Expression in HepG2 Cells." Molecules, 0, 0. (SCI)
Chen PY, Chen YT, Gao WY, Wu MJ, Yen JH.(2018), "Nobiletin Down-Regulates c-KIT Gene Expression and Exerts Antileukemic Effects on Human Acute Myeloid Leukemia Cells." J Agric Food Chem., 66, 51. (SCI)
Thang SK, Chen PY, Gao WY, Wu MJ, Pan MH, Yen JH.(2019), "Xanthohumol Suppresses NPC1L1 Gene Expression through Downregulation of HNF-4α and Inhibits Cholesterol Uptake in Caco-2 Cells.." J Agric Food Chem., 67, 40. (SCI)
Yen JH, Lin CY, Chuang CH, Chin HK, Wu MJ, and Pei-Yi Chen(2020), "Nobiletin Promotes Megakaryocytic Differentiation through the MAPK/ERK-Dependent EGR1 Expression and Exerts Anti-Leukemic Effects in Human Chronic Myeloid Leukemia (CML) K562 Cells.." Cells, 9, 0. (SCI)
Wu PS, Jeng J, Yang JJ, Kao V, Yen JH, Wu MJ(2020), "Vernonia patula (Dryand.) Merr. and Leucas chinensis (Retz.) R. Brown exert anti-inflammatory activities and relieve oxidative stress via Nrf2 activation.." Journal of Ethnopharmacology, 262, 0. (SCI)
Wu PS, Yen JH, Wang, CY, Chen PY, Hung JH, Wu MJ*(2020), "8-Hydroxydaidzein, an Isoflavone from Fermented Soybean, Induces Autophagy, Apoptosis, Differentiation, and Degradation of Oncoprotein BCR-ABL in K562 Cells.." Biomedicines, 8, 11. (SCI)
2. Gao WY, Chen PY, Hsu HJ, Lin CY, 吳明娟, Yen JH.(2021), "Tanshinone IIA Downregulates Lipogenic Gene Expression and Attenuates Lipid Accumulation through the Modulation of LXRα/SREBP1 Pathway in HepG2 Cells.." Biomedicines, 9, 0. (SCI)
Chen PY, Gao WY, Liou JW, Lin CY, Wu MJ (吳明娟), Yen JH.(2021), "Angiopoietin-Like Protein 3 (ANGPTL3) Modulates Lipoprotein Metabolism and Dyslipidemia.." Int J Mol Sci., 22, 0. (SCI)
Wu PS, Wang CY, Chen PS, Hung JH, Yen JH, 吳明娟(2021), "8-Hydroxydaidzein Downregulates JAK/STAT, MMP, Oxidative Phosphorylation, and PI3K/AKT Pathways in K562 Cells.." Biomedicines, 9, 0. (SCI)
Chen PY, Wang CY, Tsao EC, Chen YT, 吳明娟, Ho CT, Yen JH(2022), "5-Demethylnobiletin Inhibits Cell Proliferation, Downregulates ID1 Expression, Modulates the NF-κB/TNF-α Pathway and Exerts Antileukemic Effects in AML." Int J Mol Sci., 23, 0. (SCI)
P.-S. Wu, C.-Y. Wang, H.-J. Hsu, J.-H. Yen, 吳明娟(2023), "8-Hydroxydaidzein Induces Apoptosis and Inhibits AML-Associated Gene Expression in U-937 Cells: Potential Phytochemical for AML Treatment." Biomolecules, 13, 11. (SCI)
YC Liu, PS Wu, SH Teng, 吳明娟(2023), "Identification of Dominant Microbes and Functional Analysis of Sourdough Starters Made of Dried Longan and Raisin." Engineering Proceedings, 55, 0. (SCI)
P.-R. Chang, J.-W. Liou, P.-Y. Chen, W.-Y. Gao, C.-L. Wu, 吳明娟, J.-H. Yen(2023), "The Neuroprotective Effects of Flavonoid Fisetin against Corticosterone-Induced Cell Death through Modulation of ERK, p38, and PI3K/Akt/FOXO3a-Dependent Pathways in PC12 Cells." Pharmaceutics, 15, 0. (SCI)
研討會論文(2009), "The hepatic polymeric immunoglobulin receptor is down-regulated in mice fed diet containing deep frying oil.." The 19th International Congress of Nutrition, 曼谷, 泰國.
(2009), "Luteolin mimics neurotrophic factor to confer neuroprotective effect on PC12 cells and ameliorate contextual fear learning in mice." The 8th annual Molecular and Cellular Cognition Society, 芝加哥, 美國.
(2009), "Neuroprotective effect of TCU-168 against serum-deprivation and oxidative stress-induced cell death via MAPK activation and heme oxygenase-1 expression.." The 24th Joint Annual Conference of Biomedical Sciences, 台北, 台灣.
(2007), "Activation of PPAR gamma by oleanane-type triterpenoids." The 22nd Joint Annual Conference of Biomedical Sciences, 台北, 台灣.
(2007), "Free radical scavenging and tyrosinase inhibition properties of a polyphenol fraction isolated from the fruit of tree tomato (Cyphomandra betacea Sendt.)." 2007年食科年會, 彰化, 台灣.
(2010), "Mechanisms of Curcumin and its Derivatives in Promoting Cell Differentiation of PC12 Cells.." The 25th Joint Annual Conference of Biomedical Sciences, 台北, 台灣.
(2010), "Curcuminoids promote neuronal differentiationof PC12 cells through PKC-dependent phosphorylation of CREB protein." 240th ACS National Meeting, Boston, 美國.
(2011), "5-Hydroxy-3,6,7,8,3’,5’-hexamethoxyflavone, a citrus polymethoxylated flavonoid, promotes neuronal differentiation through PKA/CREB pathway in PC12 cells." Pharma-Nutrition, Amsterdam, Netherlands.
(2011), "Orange polymethoxylated flavones suppress scavenger receptor expression in THP-1 cells and alter lipid homeostasis in HepG2 liver cells." 2011台俄有機、藥物及生物化學交流研討會暨藥物化學研討會, 南投, 台灣.
MJ Wu, JH Yen(2013), "Luteolin protects against 6-hydroxydopamine-induced endoplasmic reticulum stress and induces neurite outgrowth in PC12 cells." 2013 ISNFF Conference and Exhibition, Taipei, Taiwan.
M.H. Tai, S.L. Huang, P.Y. Chen, M.J. Wu, C.T. Ho, J.H. Yen.(2013), "Curcumin decreases PCSK9 gene expression via regulation of hepatocyte nuclear factor 1α (HNF1α) in HepG2 cells.." 2013 Pharma-Nutrition, Singapore, Singapore.
Chiu SP, Wu MJ, Huang SW, Ho CT, Yen JH(2012), "Citrus 5-hydroxylated polymethoxyflavones promote neuritogenesis through cAMP response element binding protein (CREB) pathway in PC12 cells.." the 243rd ACS National Meeting, San Diego, California, USA.
HJ Tien, PY Chen, J H Chen, MJ Wu, JH Yen*(2015), "Luteolin-mediated apoptosis in leukemia cells involves PTTG1 oncoprotein and differential responses.." 245th American Chemical Society National Meeting, Boston, USA.
HC Chen, MJ Wu, PY Chen, YC Chen, MH Tai, JH Yen(2015), "Tanshinone IIA modulates cell-surface LDLR level and LDL uptake via suppression of PCSK9 gene expression in HepG2 cells.." 245th American Chemical Society National Meeting, Boston, USA.
專書, 生物技術概論 (中譯本), 高立圖書, 2006年出版(ISBN 986-412-260-6).
研究計畫柑橘類果皮多甲基類黃酮的抗血管粥狀硬化的功效及機轉探討
柑橘類黃酮影響神經細胞功能與學習記憶之分子研究
膳食植化素影響肝細胞IDOL基因表達以及調節LDLR與膽固醇代謝之分子研究
多酚類植化素影響肝細胞PCSK9基因表達與調節低密度脂蛋白膽固醇代謝
計畫主持人以動物模式探討香茹草之抗發炎功能
以試管實驗探討深層發酵之樟芝菌絲體之保肝活性
天然物對砷所誘發之血管粥狀硬化抑制機制之探討
天然物對砷所引起的粥狀血管硬化及免疫力改變之影響
具抗發炎功效的青草之抗血管粥狀硬化功效評估及分子機轉探討
產學合作計劃：舞茸菌絲體多醣的最佳生產條件及免疫調節功能探討(2/2)
產學合作計畫：舞茸菌絲體多醣的最佳生產條件及免疫調節功能探討(1/2)
類黃酮對脂泡細胞形成的分子機轉研究
六種天然物在受刺激的嗜中性單核球中的抗氧化活性評估”Evaluation of the antioxidant activities of six natural components against ROS production in stimulated PMN “
類黃酮對保護PC12類神經細胞免於氧化傷害及促進突觸生長之功能及機轉探討
具Nrf2活化功能的植化素之神經保護功效探討:內質網壓力及氧化壓力
風茹草保健膠囊與口服液之製備
鄰位氫氧化大豆異黃酮衍生物之神經保護功能探討
trypsin inhibitor移除率、抗原蛋白移除率
以植物工廠培育中草藥用於生技藥粧產品之開發: 子計畫3
科技部大專生計畫-大豆異黃酮代謝物之神經保護研究
教育部優化技職校院實作環境計畫
專業證照Google "Google Apps Education Drive Individual Qualification (IQ)" (2014/08/28)
Google "Google Apps Education Sites Individual Qualification (IQ)" (2014/08/28)
勞動部 (舊：勞工委員會) "中華民國技術士-第一種壓力容器操作" (2019/08/28)
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