姓名呂玉玲
職稱教授
聯絡電話2236
電子郵件yulin@mail.cnu.edu.tw
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期刊論文(2005), "Stability of the new prodrug 9-aminocamptothecin glucuronide (9ACG) in the presence of human serum albumin." Biochemical pharmacology, 1, 66. (SCI)
(2008), "Benzyl Ether-Linked Glucuronide Derivative of 10-Hydroxycamptothecin Designed for Selective Camptothecin-Based Anticancer Therapy.." J. Med. Chem., 51,, 1740-1746.. (SCI)
(2007), "Membrane-localized activation of glucuronide prodrugs by β-glucuronidase enzymes.." Cancer Gene Ther., 14(2):, 187-200. (SCI)
(2007), "Effect of pH and human serum albumin on the cytotoxicity of a glucuronide prodrug of 9-aminocamptothecin.." Cancer Chemother Pharmacol., 60(1):, 7-17. (SCI)
(2008), "Tumor-targeting prodrug-activating bacteria for cancer therapy.." Cancer Gene Therapy, 15(4),, 252-267. (SCI)
(2006), "Combination cancer therapy by hapten-targeted prodrug-activating enzymes and cytokines.." Bioconjugate Chemistry, 17,, 707-714. (SCI)
(2006), "A membrane antibody receptor for noninvasive imaging of gene expression.." Gene Therapy, 13,, 412-420. (SCI)
(2009), "Antiangiogenesis Targeting Tumor Microenvironment Synergizes Glucuronide Prodrug Antitumor Activity.." Clinical Cancer Research, 15, 14. (SCI)
(2008), "Directed Evolution of a Lysosomal Enzyme with Enhanced Activity at Neutral pH by Mammalian Cell-Surface Display.." Chemistry & Biology, 15, 12. (SCI)
(2012), "An Activity-Based Near-Infrared Glucuronide Trapping Probe for Imaging β-Glucuronidase Expression in Deep Tissues.." J. Am. Chem. Soc., 13, 0. (SCI)
KC Chen, SY Wu, YL Leu, ZM Prijovich, BM Chen, HE Wang, TL Cheng and SR Roffler(2011), "A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment.." Bioconjugate Chem., 22, 0. (SCI)
PT Huang, KC Chen, ZM Prijovich, TL Cheng, YL Leu and SR Roffler(2011), "Enhancement of CPT-11 antitumor activity by adenovirus-mediated expression of β–glucuronidase in tumors.." Cancer Gene Ther., 18, 0. (SCI)
彭肇堯; 鄭達駿; 鄭添祿(2012), "Synthesis and 99m Tc labeling iminoacid analogues : A hepatobiliary imaging agent in nuclear medicine." 台灣藥學會物化學研討會, 0, 0. (其他)
P Chen, YT Hsieh, ZMPrijovich, HY Chuang, KC Chen, WC Lu, Q Tseng, YLLeu, TL Cheng, SR Roffler(2012), "A humanized immunoenzyme with enhanced activity for glucuronide prodrug activation in the tumor microenvironment.." Protein Eng Des Sel., 25, 7. (SCI)
Cheng-Pao Chen1, Yuan-Ting Hsieh Zeljko M.Prijovich1, Huai-Yao Chuang Kai-Chuan Chen, Wei-Cheng Lu, Qingzong Tseng, Yu-Lin Leu, Tian-Lu Cheng and Steve R.Roffler(2012), "ECSTASY, an adjustable membrane-tethered/soluble protein expression system for the directed evolution of mammalian proteins." Protein Engineering, Design & Selection, 25, 7. (SCI)
Yu-Cheng Su, Ta-Chun Cheng, Yu-Ling Leu, Steve R. Roffler, Jaw-Yuan Wang, Chih-Hung Chuang, Chien-Han Kao, Kai-Chuan Chen, Hsin-Ell Wang, and Tian-Lu Cheng(2014), "PET Imaging of b-Glucuronidase Activity by an." Molecular Cancer Therapeutics, 13, 0. (SCI)
Ta-Chun Cheng, Kuo-Hsiang Chuang, Steve R. Roffler, Kai-Wen Cheng, Yu-Lin Leu, Chih-Hung Chuang, Chien-Chaio Huang ,Chien-Han Kao, Yuan-Chin Hsieh, Long-Sen Chang, Tian-Lu Cheng,Chien-Shu Chen(2014), "Discovery of specific inhibitors for intestinal E. Coli β-glucuronidase through in silico virtual screening." The Scientific World Journal, 0, 0. (SCI)
Prijovich, Zeljko M.; Burnouf, Pierre-Alain; Chou, Hua-Cheng; Huang, Ping-Ting; Chen, Kai-Chuan; Cheng, Tian-Lu; Leu, Yu-Lin*; Roffler, Steve R*(2016), "Synthesis and Antitumor Properties of BQC-Glucuronide, a Camptothecin Prodrug for Selective Tumor Activation." Molecular Pharmaceutics, 4, 13. (SCI)
Kai-Wen Cheng, Chih-Hua Tseng, Chia-Ning Yang, Cherng-Chyi Tzeng, Ta-Chun Cheng, Yu-Lin Leu, Yu-Chung Chuang, Jaw-Yuan Wang, Yun-Chi Lu, Yeh-Long Chen*, Tian-Lu Cheng*(2017), "Specific Inhibition of Bacterial β-Glucuronidase by Pyrazolo[4,3-c]quinoline Derivatives via a pH-Dependent Manner To Suppress Chemotherapy-Induced Intestinal Toxicity." Journal of Medicinal Chemistry, 22, 60. (SCI)
Burnouf, Pierre-Alain; Leu, Yu-Lin; Su, Yu-Cheng; Wu, Kenneth; Lin, Wei-Chi; Roffler, Steve R.(2018), "Reversible glycosidic switch for secure delivery of molecular nanocargos.." Nature Communications, 9, 2018. (SCI)
Cheng, Kai-Wen; Tseng, Chih-Hua; Tzeng, Cherng-Chyi; Leu, Yu-Lin; Cheng, Ta-Chun; Wang, Jaw-Yuan; Chang, Jia-Ming; Lu, Yun-Chi; Cheng, Chiu-Min; Chen, I-Ju(2019), "Pharmacological inhibition of bacterial β-glucuronidase prevents irinotecan-induced diarrhea without impairing its antitumor efficacy in vivo." Pharmacological Research, 2019,139,41-49, 139. (SCI)
Kai-Wen Cheng, Chih-Hua Tseng, I.-Ju Chen, Bo-Cheng Huang, Hui-Ju Liui, Kai-Wen Ho, Wen-Wei Lin, Chih-Hung Chuang, Ming-Yii Huang, Yu-Lin Leu, Steve R. Roffler, Jaw-Yuan Wang, Yeh-Long Chen, Tian-Lu Cheng(2022), "Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis." Pharmacological Research, 177, 0. (SCI)
Wen-Wei Lin, Yi-Jung Huang, Yen-Tseng Wang, Yun-Syuan Lin, Nonsikelelo Mazibuko, Chien-Shu Chen, Tian-Lu Cheng, Chih-Shiang Chang, Yu-Ling Leu, Chiao-Yun Chen,**, Chih-Hung Chuang,(2023), "Development of NS2B-NS3 protease inhibitor that impairs Zika virus replication." virus research, 329, 0. (SCI)
Yi-Han Tseng a,1 , Hsuan-Pei Lin a,1 , Sung-Yao Lin a , Bing-Mae Chen a , Thanh Nguyet Nguyen Vo a , Shih-Hung Yang a , Yi-Chen Lin a , Zeljko Prijovic b , Andreas Czosseck a , Yu-Lin Leu c , Steve R Roffler a,d,(2024), "Engineering stable and non-immunogenic immunoenzymes for cancer therapy via in situ generated prodrugs." Journal of Controlled Release, 0, 0. (SCI)
研討會論文(2011), "Micro-PET Imaging of b-Glucuronidase Activity by the Hydrophobic." 2011 Taiwanese-Russian Organic, Medicinal and Bio chemistry Interactions & PST Medicinal Chemistry Symposium, 南投, 台灣.
Chao-Yao, Peng (彭肇堯)1, Ta-Chun Cheng (鄭達駿)2, Tian-Lu Cheng (鄭添祿)3,4*, Yu-Ling Lu (呂玉玲)1* (2012), "Synthesis and 99m Tc Labeling Iminodiacetic Acid Analogues：." 2012台灣藥學會藥物化學研討會, 南投, 中華民國.
pei-Fang chiu; Kuo-Hui chen, wei-chi lin and yu-ling leu(2017), "Design and Synthesis a water-soluble group for ether-linkage of 10-hydroxycamptothecin prodrug." 2017年台灣藥學會藥物化學研討會, 南投, 中華民國.
Zeljko M. Prijovich1, Pierre-Alain Burnouf2, Ping-Ting Huang1, Kai-Chuan Chen1, Tian-Lu Cheng3, Yu-Lin Leu4*, and Steve R. Roffler1*(2017), "Synthesis and antitumor properties of BQC glucuronide, a camptothecin prodrug for selective tumor activation.." 2017中國藥物化學術會議/中歐藥物化學研討會, 北京, 中國大陸.
yu-ling, lu(2020), "beta-glucuronidase application for tumor therapy and diagnosis." 2020年度藥物化學討論交流會, 廣州/三義, 中國大陸廣州.
呂玉玲, 高念楚(2022), "在人體血中具較佳穩定性的喜樹鹼衍生物BQC之合成." 2022台灣藥學會藥物化學研討會, 台南, 中華民國.
研究計畫研發可局部活化於腫瘤的前驅分子以進行癌症照影與治療
無生產人類酵素突變體以改善癌症與溶小體肝醣儲積症之治療
廣效奈米藥物於胰臟癌的治療(1/3)
廣效奈米藥物於胰臟癌的治療(2/3)
計畫主持人設計合成水溶性喜樹鹼用於癌症的治療
血管新生抑制劑對癌細胞轉移之活性評估
活化焠熄的紅外葡萄糖酸苷前驅探針與前驅抗癌藥物以結合葡萄糖酸苷酶(G)表現腫瘤之即時造影與治療
設計合成-葡萄糖醛酸活化而落入圈套之分子探針
活體造影內生性葡萄糖醛酸活性以進行個人化前驅藥物之標靶治療
開發腸道葡萄醣醛酸酶專一性抑制劑57以降低化療誘導腹瀉及提高化療療效
開發新型廣效性抗體閉鎖器非活化治療抗體藥物進行選擇性標靶治療
開發精準標訂和主動吸引PEG奈米藥物的雙功能抗體以產生加成抗癌療效
研發api結晶初期試驗
開發腸道葡萄醣醛酸酶專一性抑制劑57以降低化療誘導腹瀉及提高化療療效
開發腸道葡萄醣醛酸酶專一性抑制劑57以降低化療誘導腹瀉及提高化療療效
SB01專案相關化合物合成研究
開可被二級抗體直接辦識且自動呈色之蛋白質標記
開發可由葡萄糖醛酸苷酶調控式之金奈米紅外光造影劑
中央研究院107年度新增主題研究計劃
以醣?;轉化包覆高量藥物於微脂體進行高效之癌症治療
治療/照影雙功能前驅藥物作為癌症的精確診斷和標靶治療1/2)
專業證照行政院衛生署 "藥師證書" (1986/04/23)
榮譽特優
績優
教學傑出教師
本校102學年度教學傑出教師
產學合作優良教師奬
103年度畢業流向調查
衛生福利部食品藥物管理署感謝狀
最佳論文奬
口頭論文優勝
第二名
104年度畢業流向調查
產學合作優良教師
2016台藥學會藥物化學研討會壁論文佳作
第十一屆藥理學院師生研究發表會
產學合作優良教師
優秀壁報奬
產學合作優良教師
第十三屆藥理學院師生研究發表會第二名
104年度畢業流向調查
第十四屆藥理學院師生研究成果發表會壁報組第壹名
第十四屆藥理學院師生研究成果發表會壁報組第二名
第十五屆藥理學院師生成果發表會
2022台灣藥學會藥物化學研討會壁報論文大學組-傑出(第一名)