姓名李冠漢
職稱特聘教授
聯絡電話2212
電子郵件kuanhanlee@mail.cnu.edu.tw
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期刊論文(2009), "Unlocking Fungal Cryptic Natural Products." Natural Product Communications, 4, 11. (SCI)
(2003), "Computer-Aided Drug Design in Drug Discovery." Chemistry, 61, 4. (其他)
(2003), "Three-Dimensional Pharmacophore Mapping of Certain Anticancer -Methylene-γ-butyrolactones." Oncology Research, 13, 0. (SCI)
(2002), "Synthesis and Cytotoxic Evaluationof α-Methylene-γ-butyrolactone Bearing Naphthalene and Naphtho[2,1-b]furan Derivatives." European J. Med. Chem., 37, 0. (SCI)
(2000), "Synthesis and Cytotoxic Evaluation of A Series of γ-Substituted γ-Aryloxymethyl-α-methylene-γ-butyrolactones Against Cancer Cells." Pharmaceutical Research, 17, 6. (SCI)
(1999), "Synthesis and Anticancer Evaluation of Certain α-Methylene-γ-(4-substituted phenyl)-γ-butyrolactone Bearing Thymine, Uracil, and 5-Bromouracil." Bioorganic & Medicinal Chemistry Letters, 0, 0. (SCI)
(1998), "Synthesis and Anticancer Evaluation of Certain α-Aryloxymethyl-α-methylene-γ-phenyl-γ-butyrolactones." Bioorganic & Medicinal Chemistry Letters, 0, 0. (SCI)
(2010), "Synthesis and antibacterial evaluation of 6-azapyrimidines with α-methylene-γ-(4-substituted phenyl)- γ-butyrolactone pharmacophores." Medicinal Chemistry Research, 0, 0. (SCI)
Somoza, A. D., Lee, K. H., Chiang, Y. M., Oakley, B. R., & Wang, C. C. C.(2012), "Reengineering an Azaphilone Biosynthesis Pathway in Aspergillus nidulans To Create Lipoxygenase Inhibitors." Organic Letter, 14, 4. (SCI)
Guo, C. J., Knox, B. P., Chiang, Y. M., Lo, H. C., Sanchez, J. F., Lee, K. H., Wang, C. C.(2012), "Molecular Genetic Characterization of a Cluster in A. terreus for Biosynthesis of the Meroterpenoid Terretonin.." Organic Letters, 14, 22. (SCI)
Lin, W. C., Chuang, Y. C., Chang, Y. S., Lai, M. D., Teng, Y. N., Su, I. J., Wang,C. C. C., Lee, K. H., Hung, J. H.(2012), "Endoplasmic Reticulum Stress Stimulates p53 Expression through NF-kappa B Activation.." Plos One, 7, 7. (SCI)
Yeh, H. H., Chiang, Y. M., Entwistle, R., Ahuja, M., Lee, K. H., Bruno, K.S.,Wang, C. C. C.(2012), "Molecular genetic analysis reveals that a nonribosomal peptide synthetase-like (NRPS-like) gene in Aspergillus nidulans is responsible for microperfuranone biosynthesis." Applied Microbiology and Biotechnology, 96, 3. (SCI)
李冠漢、呂尚謙、林怡亭、劉坤湘(2013), "白尾蜈蚣草粗萃取物應用於化粧品之保濕與抗老化能力分析." 嘉南學報, 無, 39. (其他)
Lee, K. H., Lin, Y. S., and Huang, P. J.(2013), "Design, Synthesis, and Characterization of Novel Thiol-Derivatized Ibuprofen Monolayer Protected Gold Clusters." Journal of Nanomaterials, 0, 0. (SCI)
Lee KH, Ho WY, Wu SJ, Omar HA, Huang PJ, Wang CC, Hung JH.(2014), " Modulation of Cyclins, p53 and Mitogen-Activated Protein Kinases Signaling in Breast Cancer Cell Lines by 4-(3,4,5-Trimethoxyphenoxy)benzoic Acid.." Int J Mol Sci, 15, 1. (SCI)
Lee KH, Ho WY, Wu SJ, Cheng TL, Huang PJ, Wang CC, Hung JH.(2014), "Behavior-selective Apoptotic Capacity of 4-(3,4,5-Trimethoxyphenoxy) Benzoic Acid and its Methyl Derivatives on Two Breast Cancer Cell Lines.." Anticancer Res., 34, 4. (SCI)
Lee KH, Wu CJ, Wang CC, Hung JH.(2012), "Prevention of chronic HBV infection induced hepatocellular carcinoma development by using antiplatelet drugs.." Hepatobiliary Surg Nutr., 1, 1. (SCI)
Kuan Han Lee, Hui Ping Tang, Shiaw Wei Tyan, Kun Hsiang Liu, Jui Hsiang Hung(2014), "Induction of cytotoxicity by Manila Palm Seed Extracts in Hepatocellular Carcinoma Cells.." 嘉南學報, 0, 40. (其他)
Jung-Ju Wu , HanyA.Omar , Ying-RayLee , Yen-NiTeng , Pin-ShernChen,Yu-ChungChen , Hsiao-ShanHuang , Kuan-HanLee , Jui-HsiangHung(2015), "6-Shogaol inducescellcyclearrestandapoptosisinhumanhepatoma cells throughpleiotropicmechanisms.." EuropeanJournalofPharmacology, 449-458, 762. (SCI)
1. Chaiyan, W., Anuchapreeda, S., Punyoyai, C., Neimkhum, W., Lee, K. H., Lin, W. C., Lue, S. C., Viernstein, H., Mueller, M(2019), "Ocimum sanctum Linn. as a natural source of skin anti-ageing compounds. Industrial crops and products,." Industrial crops and products, 127, 0. (SCI)
Teen-Hang Meen, Yusuke Matsumoto and Kuan-Han Lee(2020), "Special Issue on Clinical Medicine for Healthcare and Sustainability." Journal of Clinical Medine, 9, 0. (SCI)
Wantida Chaiyana, Songyot Anuchapreeda, Suvimol Somwongin, Pachabadee Marsup, Kuan-Han Lee, Wei-Chao Lin, Shang-Chian Leu(2020), "Dermal Delivery Enhancement of Natural Anti-Ageing Compounds from Ocimum sanctum Linn. Extract by Nanostructured Lipid Carriers." pharmaceuticals, 12, 0. (SCI)
Wantida Chaiyana, Sunee Chansakaow, Nutjeera Intasai, Kanokwan Kiattisin, Kuan-Han Lee, Wei-Chao Lin, Shang-Chian Lue and Pimporn Leelapornpisid(2020), "Chemical Constituents, Antioxidant, Anti-MMPs, and Anti-Hyaluronidase Activities of Thunbergia laurifolia Lindl. Leaf Extracts for Skin Aging and Skin Damage Prevention." molecules, 25, 0. (SCI)
Pimjai Doungsaard, Sunee Chansakaow, Jakkapan Sirithunyalug, Lue Shang-Chian, Lin Wei-Chao, Liang Chia-Hua, Lee Kuan-Han and Pimporn Leelapornpisid1(2020), "In vitro Biological Activities of the Anti-aging Potential of Dimocarpus longan Leaf Extracts." CMU J. Nat. Sci., 9, 2. (其他)
Shun-Fu Chang, Kuo-Chin Huang, Kuan-Han Lee, Yao-Chang Chiang, Wei-Ru Lee, Rong-Ze Hsieh, Yu-Ping Su and Shun-Chi Wu(2021), "Effects of Visfatin on Intracellular Mechanics and Catabolism in Human Primary Chondrocytes through Glycogen Synthase Kinase 3β Inactivation." Int. J. Mol. Sci., 0, 22. (SCI)
Waranya Neimkhum, Songyot Anuchapreeda, Wei-Chao Lin, Shang-Chian Lue, Kuan-Han Lee and Wantida Chaiyana(2021), "Effects of Carissa carandas Linn. Fruit, Pulp, Leaf, and Seed on Oxidation, Inflammation, Tyrosinase, Matrix Metalloproteinase, Elastase, and Hyaluronidase Inhibition." Antioxidants, 0, 10. (SCI)
Lee, C. W., Vo, T. T. T., Wee, Y, Chiang, Y. C., Chi, M. C., Chen, M. L., Hsu, L. F., Fang, M. L., Lee, K. H., Guo, S.E., Cheng, H. C., Lee, I. T.(2021), "The Adverse Impact of Incense Smoke on Human Health: From Mechanisms to Implications." Journal of Inflammatory Research, 0, 14. (SCI)
Chen, S. C., Lee, K. H., Horng, D. J., Huang, P. J.(2021), "Integrating the Public Health Services Model into Age-Friendly Pharmacies: A Case Study on the Pharmacies in Taiwan." Healthcare, 0, 9. (SCI)
Lee, C. W., Chiang, Y. C., Yu, P. A., Peng, K. T., Chi, M. C., Lee, M. H., Fang, M. L., Lee, K. H., Hsu, L. F., Liu, J. F.(2021), "A Role of CXCL1 Drives Osteosarcoma Lung Metastasis via VCAM-1 Production." frontiers in Oncology, 0, 11. (SCI)
Chiang-Wen Lee, Cathy Chia-Yu Huang, Miao-Ching Chi, Kuan-Han Lee, Kuo-Ti Peng, Mei-Ling Fang, Yao-Chang Chiang , and Ju-Fang Liu(2022), "Naringenin Induces ROS-Mediated ER Stress, Autophagy, and Apoptosis in Human Osteosarcoma Cell Lines." Molecules, 27, 2. (SCI)
Tzu-Ling Tseng, Wen-Yueh Ho, Po-Jui Huang, Jin-Zhi Lia, Kuan-Han Lee(2022), "Oroxylin-A and its phosphonate derivative potentiate eNOS/NO-mediated relaxation and attenuate vasoconstrictor-induced contraction in the mouse aorta." Journal of Pharmacological Sciences, 150, 0. (SCI)
Waranya Neimkhum, Songyot Anuchapreeda, Wei-Chao Lin, Shang-Chian Lue, Kuan-Han Lee, Wantida Chaiyana(2023), "Enhancement of stability and dermal delivery of Carissa carandas Linn. leaf extract by liquid crystals." Journal of Drug Delivery Science and Technology, 82, 0. (SCI)
Waranya Neimkhum, Songyot Anuchapreeda, Wei-Chao Lin, Shang-Chian Lue, Kuan-Han Lee, Wantid Chaiyana(2023), "Enhancement of stability and dermal delivery of Carissa carandas Linn. leaf extract by liquid crystals." Journal of Drug Delivery Science and Technology, 82, 0. (SCI)
研討會論文(2009), "Synthetic Studies on Certain Ibuprofen Nanogold Prodrugs." Annual Meeting of Chinese Pharmaceutical Society, Taipei, TW.
(2010), "Discovery of Telomerase Inhibitors by a Virtual Screening Approach Based on Pharmacophore and 3D Shape Modeling." The 7th International Symposium for Chinese Medicinal Chemists (ISCMC-2010), Kaohsiung, TW.
(2008), "Grid Enabled MPI (GEM) System: Toward Maximum Computational Efficiency in Molecular Docking and Virtual Screening." The 5th Conference of Channel-bridge Chemistry, Biology and Material Science, Tainan, TW.
(2007), "Ester-Derived Nanoprodrug of Nonsteroidal Antiinflammatory Drugs." Annual Chinese Chemical Society & ICCT 2007 Joint Conference, Hsichu, Taiwan.
(2007), "Pharmacophore Development and Shape-Based Search of Certain Telomerase Inhibitors." Annual Chinese Chemical Society & ICCT 2007 Joint Conference, Hsinchu, Taiwan.
(2009), "Synthetic Studies on Certain Ibuprofen Derivated Nano-prodrugs." 2009 Annual Meeting of Chemical Society Loacted in Taipei, Kaohsiung, TW.
(2010), "Amide Derivatives of Ibuprofen as Novel Antiinflammatory Nano-Prodrugs." The 7th International Symposium for Chinese Medicinal Chemists, Kaohsiung, TW.
(2009), "Synthetic Studies on Certain Ibuprofen Derivated Nano-prodrugs." 2009 Annual Meeting of Chemical Society Loacted in Taipei, Kaohsiung, TW.
(2010), "Synthetic and cytotoxic studies on certain diaryl ethers." 99年度台灣藥學會年會暨學術研討會, Taipei, Taiwan.
(2010), "Pharmacophore Development and Shape-based Search of Certain Telomerase Inhibitors." The 23th Federation of Asian Pharmaceutical Associations Congress, Taipei, Taiwan.
Chao YY, Lu MY,Chen LY, Yang TS, Huang PJ, Lee KH(2011), "Investigation on the Optimal Conditions for the Production of Acetylaszonalenin by Neosartorya fischer." 台灣藥學會年會, 台灣屏東, 中華民國.
Chao YY, Lue SC, Lee KH(2012), "Investigation on factors affecting acetylaszonalenin production by Neosartorya fischeri." 13th Tetrahedron Symposium---Asia Edition, 台北, 中華民國.
Liu KH, Liao JL, Lue SC, Lee KH(2012), "Cloning and characterization of novel LaeA and VeA genes in Antrodia cinnamomea." 13th Tetrahedron Symposium---Asia Edition, 台北, 中華民國.
Lue SC, Liu KH, Chao YY, Hsu CJ, Yang TS, Lee KH(2012), "Acetylaszonalenin production by Neosartorya fischeri as affected by initial pH, temperature, and nutrient source." 中國畫學會年會, 台南, 中華民國.
劉坤湘.呂尚謙.林秋燕.陳雅郁.李冠漢(2013), "牛樟芝菌絲體發酵液抑制HIV-1反轉錄?;活性之研究." 中國化學年會, 台中, 台灣.
楊宗憲.張伊玲.呂尚謙.劉坤湘.李冠漢(2013), "冬蟲夏草二次代謝物之生物活性研究." 台灣藥學會, 台北, 台灣.
劉坤湘.呂尚謙.林秋燕.黃亦偉.陳雅郁.李冠漢(2014), "The Laccase with HIV-1 Reverse Transcriptase Inhibitory Activity from Broth of Mycelial Culture of the Antrodia cinnamomea.." 第29屆生物醫學聯合學術年會, 台北, 台灣.
張伊玲.何文岳.呂尚謙.劉坤湘.李冠漢(2014), "Genomic Mining of Aspergillus terreus: The Semibiosynthesis of Acetylaszonalenin and Its Analogues in △anaPS Mutant.." 第29屆生物醫學聯合學術年會, 台北, 台灣.
張伊玲.何文岳.呂尚欠.劉坤湘.李冠漢(2014), "Genomic Mining of Aspergillus terreus: The Semibiosynthesis of Acetylaszonalenin and Its Analogues in △anaPS Mutant.." 第八屆藥理學院師生研究成果發表會, 台南, 台灣.
張伊玲.何文岳.呂尚謙.劉坤湘.李冠漢(2014), "Aspergillus terreus ana 基因叢集之二次代謝物基因探勘及半生合成之研究." 中國化學會高雄分會年會暨「美麗的推手-化粧品」研討會, 台南, 台灣.
kun-Hsiang Liu, Yu-Chun Lu,Wen-Yueh Ho,Shang-Chian Lue, kuan-Han Lee(2015), "A Semi-biosynthetic Platform for Fungal Secondary Metabolites from Aspergillus terreus and Neosartorya fischeri." 2015 生物技術暨生物工程國際研討會, 台北, 中華民國.
Yi-Ling Chang, Wen-Yueh Ho, Kun-Hsiang Liu, Shang-Chian Lue, Kuan-Han Lee(2014), "Semi-Biosyntheis of Acetylaszonalenin and Its Analogues in anaPS Deletion Mutant.." 台灣基因醫學年會, 台北, 中華民國.
張伊伶,何文岳, 劉坤湘, 呂尚謙, 李冠漢(2014), "Aspergillus terreus二次代謝物半生合成之研究." 綠色化學與永續能源, 新竹, 中華民國.
Ming-Syuan Wu, Wei-De Wu, Kuan-Han Lee, Shiaw Wei Tyan, Kun Hsiang Liu, Pin-Shern Chen, Yu-Chung Chen, Clay C. C. Wang, Jui-Hsiang Hung(2015), "6-Shogaol induces cell cycle arrest and apoptosis in human hepatoma cells through pleiotropic mechanisms.." 中草藥保健暨香粧產品研討會, 屏東, 中華民國.
劉坤湘,盧郁淳,葉旭華,呂尚謙,李冠漢(2015), "費氏麴菌二次代謝物之生物活性分析." 中草藥保健暨香粧產品研討會, 屏東, 中華民國.
呂尚謙,朱冠潔,李冠漢(2015), "中草藥醱酵物應用於化粧品之功能性評估." 中草藥保健暨香粧產品研討會, 屏東, 中華民國.
Hsu-Hua Yeh, Shu-Lin Chang, Yi-Ming Chiang, Clay Wang,Kuan-Han Lee(2015), "Identification and Characterization of Monascus ruber Secondary Metabolite Biosynthetic Products.." 中草藥保健暨香粧產品研討會, 屏東, 中華民國.
Shu-Lin Chang, Hsu-Hua Yeh, Yi-Ming Chiang, Clay Wang, Kuan-Han Lee(2015), "Reconstitution of the gliotoxin biosynthesis using a bottom-upheterologous expression system.." 中草藥保健暨香粧產品研討會, 屏東, 中華民國.
洪瑞祥,何文岳,黃博瑞,王嘉駿,李冠漢(2015), "雙苯基醚化合物之合成與其抑制乳癌細胞生長研究." 中草藥保健暨香粧產品研討會, 屏東, 中華民國.
Shang-Chian Lue, Guan-Jie Jhu, Yu-Yang Chao, Wen-Yueh Ho, Kun-Hsiang Liu, and Kuan-Han Lee(2015), "Evaluation of Secondary Metabolites from the Filamentous Fungus Neosartorya fischeri NRRL 181.." 2015 生物技術暨生物工程國際研討會, 台北, 中華民國.
呂尚謙.林秋燕.何文岳.李冠漢(), "利用突變性半生物合成模式於Neosartorya fischeri基因轉型株以前驅物餵養方式製造Acetylaszonalenin." 105年台灣要學會年會暨學術研討會, 台北, 台灣.
張書林.葉旭華.江一民.李冠漢.王嘉駿(2016), "Characterization of the chemical product of NR-PKSs in Monascus using heterologous expression approach." 105年台灣要學會年會暨學術研討會, 台北, 台灣.
劉坤湘.葉昱彤.洪文傑.王嘉駿.李冠漢(2016), "Bioactivity studies of major secondary metabolites from Neosartorya fischeri." 105年台灣要學會年會暨學術研討會, 台北, 台灣.
李冠漢、溫孟蓉(2018), "以3D QSAR方法由紅麴色素開發新穎性之黑色素生成抑制劑." 第一屆台灣藥學聯合學術研討會, 台南, 台灣.
李冠漢、徐君馥(2018), "台灣與日本藥學教育之比較：以嘉南藥理大學與日本東北醫科藥科大學為例." 第一屆台灣藥學聯合學術研討會, 台南, 台灣.
無(2019), "Pharmaceutical Care in Taiwan: Past, Present and Future." IEEE Eurasia Conference on Biomedical Engineering, Healthcare and Sustainability, 沖繩, 日本.
Jui-Le Chen, Yi-Ching Wu, Hsin-Ho Chiu, Shu Chen, Cheng-Pang Chen, Po-Jui-Huang, Kuan-Han Lee*(2023), "Exploring Alternatives for Skin Sensitization Assessment: Optimization of Prediction Models with OECD QSAR Toolbox." 第十二屆「全人醫療暨整合服務研討會暨國際論壇」, 桃園, 台灣.
Jui-Le Chen, Yi-Ching Wu, Hsin-Ho Chiu, Shu Chen, Cheng-Pang Chen, Po-Jui-Huang, Kuan-Han Lee*(2023), "Enhancing Skin Sensitization Prediction Accuracy: Integrating Machine Learning Techniques with the QSAR Toolbox in Alternative Methods." 2023亞洲藥學會, 台北, 中華民國.
Chia-Hua Lianga, Pei-Fen Wub, Yu-Chia Wangb, Hung-Yu Lin, Pei-Chi Chiang, Po-Jui Huang, Kuan Han Lee*(2023), "Beyond Traditional Utilization of Rhubarb: Elucidating the Enhanced Bioactivities Conferred by Microbial Fermentation." 2023亞洲藥學會, 台北, 中華民國.
專書, 有機化學, 滄海書局, 2005年出版(ISBN 9578355491).
, 有機化學, 滄海書局, 2008年出版(ISBN 9578355491).
李冠漢, 生物技術製藥概論, 滄海圖書資訊公司, 2011年無月出版(ISBN 9789572890721).
計畫主持人2011年台俄有機、藥物及生物化學交流研討會
A. nidulans之orsellinic acid/F9775基因叢集二次代謝物及其衍生物之3D-QSAR與虛擬篩選研究
人類臍帶間質幹細胞與人類臍帶血造血幹細胞在實驗性熱中風的療效比較
無金三寶健康飲降低關節發炎功能之研究
真菌Neosartorya fischeri之基因探勘：Ana基因叢集調控與其二次代謝物半生合成及其生物活性研究
真菌Neosartorya fischeri之ana基因從即予二次代謝物之基因探勘、半生合成與生物活性研究
麴菌基因探勘及二次代謝物之生合成與活性研究
重組活化第七凝血因子在實驗性熱中風誘發血管內皮損傷之修護角色
以咖啡豆為基材進行真菌固態醱酵研發計畫
機能性清洗用化妝品研究開發
功能性清潔化妝品研究開發
牛樟芝與中草藥生物轉化產物之生技保健食品開發計畫
LAB細菌功能性篩選之研究
107年度精進藥品檢驗方法與技術規範
107年度加速現代化藥品檢驗規範
108年度精進藥品檢驗方法與技術規範
精進藥品檢驗方法與技術規範
精進藥品檢驗方法與技術規範
106年度「精進藥品檢驗方法與技術規範 」委託辦理計畫
109年度「精進藥品檢驗方法與技術規範 」委託辦理計畫
111年度「精進藥品檢驗方法與技術規範 」委託辦理計畫
113年度「優化藥品檢驗技術與品質規範」委託辦理計畫
專業證照考試院 / 考選部 / 衛生署 "專門職業及技術人員考試 - 藥師" (1986/07/04)
(TAF)Taiwan Accreditation Foundation[財團法人全國認證基金會] "實驗室認證規範ISO/IEC 17025" (2020/07/22)
教育部 "閩南語語言能力" (2021/12/20)
Chinese Taipei Pickleball Association[中華民國匹克球協會] "匹克球裁判證" (2022/04/01)
榮譽產學合作優良教師獎
論文壁報比賽--佳作
壁報論文比賽第一名
104學年度產學合作優良教師獎